Endocrine Abstracts

Introduction: Graves’ disease (GD) is organ-specific autoimmune-inflammatory disorder characterized by a complex pathogenesis. The inflammatory process is dominated by an imbalance of the antioxidant-oxidant mechanism, increased production of reactive oxygen species (ROS), which can potentiate the cytotoxicity of neutrophils and sustain the autoimmune process and perpetuate the disease. Aim: to study the level of ROS synthesis by peripheral blood neutrophils in patients w...

Background: Oxidative stress is involved in the pathogenesis of Graves hyperthyroidism (GH) and a disbalance of the cell redox state is associated with thyroid hyperfunction and the reccurence of the disease. Aim: To study the level of reactive oxygen species (ROS) and NAD(P)-dependent dehydrogenases of peripheral blood neutrophils in patients with compensated and relapse GH ongoing thiamazole. Materials and Methods: The study incl...

Background: Increased production of reactive oxygen species (ROS) and oxidative stress play a significant role in the initiation and persistence of the autoimmune process in Graves’ disease (GD)Aim: To study the ROS level of peripheral blood monocytes in patients with GD after radioactive iodine (RAI). Materials and Methods: The study included 48 patients with a confirmed diagnosis of GD, from 18 to 65 years (mean 46.42 ± 1...

The cellular structures lipid peroxidation related to immune system dysfunction seems to have a key role in autoimmune theory of Graves’ disease (GD). Aim: to investigate chemiluminescent (CL) activity of blood neutrophilic granulocytes in patients with GD. Materials and methods: Twenty six women, mean age 40.7±13.2, with manifestation of GD up to antithyroid therapy and 30 sex- and age-matched healthy subjects were examined. Serum thyroid hormone concentrations were...

Background: Thyroid hormones participate in maturation, differentiation and triggering of immunity, but little is known about the modulating role of thyroid hormones on intracellular enzymatic reactions of immune cells and their role in immunopathogenesis of Graves’ disease (GD).Methods: The activity of NAD(P)-dependent dehydrogenases in lymphocytes and neutrophils ofperipheral blood was studied in a group of 145 women with GD, 53 (36.5%) pati...